Mitsuhiro Osame Selected Research

Tropical Spastic Paraparesis (Tropical Spastic Paraplegia)

4/2008	Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
3/2008	Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease.
12/2007	Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide.
9/2006	Zidovudine plus lamivudine in Human T-Lymphotropic Virus type-I-associated myelopathy: a randomised trial.
7/2006	Flow cytometry evaluation of the T-cell receptor Vbeta repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals: effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
1/2006	Genetic variability in the extracellular matrix protein as a determinant of risk for developing HTLV-I-associated neurological disease.
10/2005	A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis.
5/2005	ApaI polymorphism of vitamin D receptor gene is associated with susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in HTLV-1 infected individuals.
11/2004	Longer dinucleotide repeat polymorphism in matrix metalloproteinase-9 (MMP-9) gene promoter which correlates with higher HTLV-I Tax mediated transcriptional activity influences the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP).
10/2004	Polymorphism in the interleukin-10 promoter affects both provirus load and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.

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Mitsuhiro Osame Research Topics

Disease

17	Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) 04/2008 - 01/2002
8	Spinal Cord Diseases 04/2008 - 07/2003
5	Infections 12/2007 - 04/2002
4	Pneumonia (Pneumonitis) 11/2008 - 05/2007
4	Chronic Obstructive Pulmonary Disease (COPD) 01/2008 - 12/2005
4	Disease Progression 12/2007 - 01/2002
4	Asthma (Bronchial Asthma) 04/2007 - 02/2004
3	Churg-Strauss Syndrome (Allergic Angiitis) 09/2008 - 02/2006
3	Neoplasms (Cancer) 09/2006 - 10/2002
3	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 05/2006 - 01/2002
3	Isaacs Syndrome (Neuromyotonia) 08/2005 - 01/2002
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 07/2004 - 03/2002
2	Virus Diseases (Viral Diseases) 10/2011 - 07/2003
2	Fibrosis (Cirrhosis) 11/2008 - 03/2006
2	Neutropenia 10/2008 - 07/2004
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 10/2008 - 07/2004
2	Disease Susceptibility (Diathesis) 12/2007 - 03/2005
2	Lung Diseases (Lung Disease) 06/2007 - 05/2005
2	Eosinophilia 02/2007 - 02/2004
2	Vasculitis (Vasculitides) 10/2006 - 02/2006
2	Systemic Vasculitis 10/2006 - 02/2006
2	Muscular Dystrophies (Muscular Dystrophy) 09/2006 - 07/2006
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2006 - 04/2003
2	Idiopathic Pulmonary Fibrosis 03/2006 - 05/2005
2	Bronchitis 02/2006 - 04/2003
2	Alexander Disease (Alexander's Disease) 10/2003 - 03/2002
1	Arthritis (Polyarthritis) 09/2008
1	Multiple Sclerosis 04/2008
1	Acquired Immunodeficiency Syndrome (AIDS) 03/2008
1	Nervous System Diseases (Neurological Disorders) 01/2008
1	Inclusion Body Myositis 01/2008
1	Meningitis 01/2008
1	Thymoma (Thymic Carcinoma) 12/2007
1	Myasthenia Gravis 12/2007
1	Atherosclerosis 09/2007
1	Bronchiectasis 08/2007
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/2007
1	Lactic Acidosis 04/2007
1	Hypokalemia 04/2007
1	Lung Neoplasms (Lung Cancer) 02/2007
1	Respiratory Insufficiency (Respiratory Failure) 01/2007
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2007
1	Bronchial Spasm 01/2007
1	Neurologic Manifestations (Neurological Manifestations) 11/2006
1	Urinary Tract Infections (Urinary Tract Infection) 10/2006
1	Neoplasm Metastasis (Metastasis) 09/2006
1	Brain Neoplasms (Brain Tumor) 09/2006
1	Scleroatonic muscular dystrophy 09/2006
1	Adenocarcinoma of Lung 09/2006
1	Minicore Myopathy with External Ophthalmoplegia 07/2006

Drug/Important Bio-Agent (IBA)

7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2007 - 05/2002
5	Discoidin Domain Receptor 1IBA 11/2008 - 05/2005
4	Tiotropium Bromide (Spiriva)FDA Link 01/2008 - 05/2006
4	Pharmaceutical PreparationsIBA 08/2007 - 05/2006
4	DNA (Deoxyribonucleic Acid)IBA 09/2002 - 01/2002
3	Member 10c Tumor Necrosis Factor ReceptorsIBA 09/2008 - 07/2004
3	AntibodiesIBA 04/2008 - 09/2004
3	oxitropium (oxitropium bromide)IBA 01/2008 - 05/2006
3	Adrenal Cortex Hormones (Corticosteroids)IBA 08/2007 - 05/2006
3	Interferon-alpha (Interferon Alfa)IBA 08/2007 - 01/2004
3	CytokinesIBA 12/2005 - 10/2002
2	Antiviral Agents (Antivirals)IBA 10/2011 - 07/2003
2	plerixafor FDA Link 11/2008 - 05/2007
2	Bleomycin (Blenoxane)FDA LinkGeneric 11/2008 - 05/2007
2	ChemokinesIBA 11/2008 - 05/2005
2	TNF-Related Apoptosis-Inducing LigandIBA 10/2008 - 07/2004
2	EnzymesIBA 01/2008 - 10/2002
2	MidkineIBA 01/2008 - 01/2002
2	HLA-DRB1 Chains (HLA DRB1)IBA 12/2007 - 03/2005
2	Bronchodilator Agents (Bronchodilators)IBA 01/2007 - 05/2006
2	CollagenIBA 03/2006 - 05/2005
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2005 - 11/2004
2	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 08/2005 - 09/2004
2	Glial Fibrillary Acidic ProteinIBA 10/2003 - 03/2002
2	Mitochondrial DNA (mtDNA)IBA 04/2003 - 06/2002
2	AntigensIBA 06/2002 - 05/2002
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 04/2008
1	CX3C Chemokine Receptor 1IBA 03/2008
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2008
1	HTLV-I AntibodiesIBA 01/2008
1	Heparin (Liquaemin)FDA LinkGeneric 01/2008
1	Nerve Growth Factors (Neurotrophins)IBA 01/2008
1	Peptides (Polypeptides)IBA 12/2007
1	Complementarity Determining Regions (Complementarity Determining Region)IBA 12/2007
1	Procaterol (Pro-Air)IBA 04/2007
1	Caspase 3 (Caspase-3)IBA 02/2007
1	Polymyxin B (Aerosporin)FDA LinkGeneric 01/2007
1	AnthelminticsIBA 11/2006
1	NucleosidesIBA 09/2006
1	Lamivudine (Epivir)FDA Link 09/2006
1	Zidovudine (Retrovir)FDA LinkGeneric 09/2006
1	Gefitinib (Iressa)FDA Link 09/2006
1	Small Interfering RNA (siRNA)IBA 09/2006
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 07/2006

Therapy/Procedure

6	Therapeutics 08/2007 - 01/2004
1	Thymectomy 12/2007
1	Traction 08/2007
1	Aftercare (After-Treatment) 02/2007
1	Hemoperfusion 01/2007
1	Drug Therapy (Chemotherapy) 09/2006